Learning about clinical trials: The Western multicentre, randomized, double-blind, placebo-controlled clinical trial on the effect of caffeine on alertness and cardiovascular parameters

Journal Article

With an increased emphasis on evidence-based medicine, teaching epidemiology and biostatistics to medical students is becoming increasingly important. This article discusses the development and implementation of a procedure for demonstrating the principles of clinical trials to medical students. A practical group exercise was used instead of traditional, lecture-based teaching. The students were both investigators and subjects in a placebo-controlled, randomized clinical trial involving caffeine. This trial is presented and discussed. In general, the students found the exercise to be an effective and enjoyable alternative to a traditional, didactic teaching session. Practical suggestions for educators who may be interested in using this approach in their own teaching are given.

Full Text

Duke Authors

Cited Authors

  • Østbye, T; Pause, C; Meissner, O; Feagan, B; Brown, JE; Strasberg, HR; Dodge, J

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 20 / 2

Start / End Page

  • 127 - 132

International Standard Serial Number (ISSN)

  • 0142-159X

Digital Object Identifier (DOI)

  • 10.1080/01421599881237

Citation Source

  • Scopus