Molecular targets for new antifungal drugs

Journal Article

Fungal infections in man and animals have a significant impact on health. However, there are only a few antifungal agents available for treatment of invasive mycoses. Further understanding of fungal molecular pathogenesis in collaboration with biochemistry and molecular modeling strategies should be able to develop new selective fungicidal agents. An example of this approach is Cryptococcus neoformans, which is reviewed in this discussion, as a model system for identification of antifungal molecular targets. Key words: antifungals, fungi, treatment, cryptococcosis, molecular biology, targets.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR

Published Date

  • December 31, 1995

Published In

Volume / Issue

  • 73 / S1

Start / End Page

  • 1187 - 1191

Published By

International Standard Serial Number (ISSN)

  • 0008-4026

Digital Object Identifier (DOI)

  • 10.1139/b95-377


  • en