Sociotropy and autonomy: relationship to antidepressant drug treatment response and endogenous-nonendogenous dichotomy.

Journal Article (Clinical Trial;Journal Article)

This study evaluated the relationship of sociotropic and autonomous personality traits with response to pharmacotherapy for 217 depressed outpatients using the Sociotropy-Autonomy Scale. Sociotropy was related to nonendogenous depression, whereas autonomy was related to endogenous depression. Subjects who had high autonomous-low sociotropic traits showed greater response to antidepressants (and greater drug-placebo differences) than those who had high sociotropic-low autonomous traits (who showed no drug-placebo differences). Hierarchical multiple regression analysis showed that the sociotropy-autonomy, but not the endogenous-nonendogenous, distinction was a predictor of drug treatment response. The combination of endogeneity and autonomy predicted response to placebo. If replicated, these findings may enable better matching of patient traits to various treatment modalities for depression.

Full Text

Duke Authors

Cited Authors

  • Peselow, ED; Robins, CJ; Sanfilipo, MP; Block, P; Fieve, RR

Published Date

  • August 1992

Published In

Volume / Issue

  • 101 / 3

Start / End Page

  • 479 - 486

PubMed ID

  • 1386856

International Standard Serial Number (ISSN)

  • 0021-843X

Digital Object Identifier (DOI)

  • 10.1037//0021-843x.101.3.479


  • eng

Conference Location

  • United States