Quantitative CT: Technique dependency of volume assessment for pulmonary nodules


Conference Paper

Current lung nodule size assessment methods typically rely on one-dimensional estimation of lesions. While new 3D volume assessment techniques using MSCT scan data have enabled improved estimation of lesion size, the effect of acquisition and reconstruction parameters on accuracy and precision of such estimation has not been adequately investigated. To characterize such dependencies, we scanned an anthropomorphic thoracic phantom containing synthetic nodules with different protocols, including various acquisition and reconstruction parameters. We also scanned the phantom repeatedly with the same protocol to investigate repeatability. The nodule's volume was estimated by a clinical lung analysis software package, LungVCAR. Accuracy (bias) and precision (variance) of the volume assessment were calculated across the nodules and compared between protocols via Generalized Estimating Equation analysis. Results suggest a strong dependence of accuracy and precision on dose level but little dependence on reconstruction thickness, thus providing possible guidelines for protocol optimization for quantitative tasks. © 2010 SPIE.

Full Text

Duke Authors

Cited Authors

  • Chen, B; Richard, S; Barnhart, H; Colsher, J; Amurao, M; Samei, E

Published Date

  • December 1, 2010

Published In

Volume / Issue

  • 7622 / PART 2

International Standard Serial Number (ISSN)

  • 1605-7422

International Standard Book Number 13 (ISBN-13)

  • 9780819480231

Digital Object Identifier (DOI)

  • 10.1117/12.845493

Citation Source

  • Scopus