Cholecystokinin, diet palatability, and feeding regulation in rats.

Journal Article (Journal Article)

Rats ate less food than normal on cyclic-ratio schedules following cholecystokinin and lithium chloride injections. Nevertheless, they defended this lower eating rate in the same way as under control conditions. The pattern of effects produced by cholecystokinin and lithium chloride resembled those following diet adulteration with citric acid and sucrose octa acetate and differed from the effects produced by increases in body weight. Cholecystokinin and lithium chloride injections also produced similar changes in the free-feeding patterns of non-deprived rats: Both meal size and intermeal intervals decreased in manner similar to the effects of citric acid and sucrose octa acetate adulteration. Interpreted in terms of a static regulatory model, these results suggest that cholecystokinin and lithium chloride suppress feeding by degrading the palatability of food, not by promoting satiety, discomfort, or illness.

Full Text

Duke Authors

Cited Authors

  • Ettinger, RH; Thompson, S; Staddon, JE

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 36 / 5

Start / End Page

  • 801 - 809

PubMed ID

  • 3012607

Electronic International Standard Serial Number (EISSN)

  • 1873-507X

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/0031-9384(86)90435-x


  • eng