Acute kidney injury in HIV-infected patients.


Journal Article (Review)

Acute kidney injury is common in human immunodeficiency virus (HIV)-infected patients, and has been associated with increased morbidity and mortality. Before the introduction of effective antiretroviral therapy, acute kidney injury in HIV-positive patients was most commonly the result of volume depletion, septicemia, or nephrotoxic medications. Acute kidney injury remains a significant problem in the antiretroviral era, and still commonly is attributed to infection or nephrotoxic medications. Less common causes such as direct infectious insults, immune restoration inflammatory syndrome, rhabdomyolysis, and obstruction should be considered when the underlying process is not obvious. In addition to advanced HIV disease, several other patient characteristics have emerged as potential risk factors for acute kidney injury in the antiretroviral era, including older age, diabetes, pre-existing chronic kidney disease, and hepatitis co-infection or liver disease.

Full Text

Duke Authors

Cited Authors

  • Kalim, S; Szczech, LA; Wyatt, CM

Published Date

  • November 2008

Published In

Volume / Issue

  • 28 / 6

Start / End Page

  • 556 - 562

PubMed ID

  • 19013326

Pubmed Central ID

  • 19013326

International Standard Serial Number (ISSN)

  • 0270-9295

Digital Object Identifier (DOI)

  • 10.1016/j.semnephrol.2008.08.008


  • eng

Conference Location

  • United States