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Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease.

Publication ,  Journal Article
Armstrong, FD; Thompson, RJ; Wang, W; Zimmerman, R; Pegelow, CH; Miller, S; Moser, F; Bello, J; Hurtig, A; Vass, K
Published in: Pediatrics
June 1996

Brain magnetic resonance imaging (MRI) and neuropsychological evaluations were conducted to determine whether neuroradiographic evidence of infarct in children with sickle cell disease between ages 6 and 12 years would result in impairment in cognitive and academic functioning.Children enrolled in the Cooperative Study of Sickle Cell Disease were evaluated with brain MRI and neuropsychological evaluation. Completed studies were obtained for 194 children, 135 with HbSS. MRIs were categorized according to the presence of T2-weighted, high-intensity images suggestive of infarct and were further categorized on the basis of a clinical history of cerebrovascular accident (CVA). An abnormal MRI but no clinical history of CVA was classified as a silent infarct. Neuropsychological evaluations included assessment of both global intellectual functioning and specific academic and neuropsychological functions.Central nervous system (CNS) abnormalities were identified on MRI in 17.9% of the children (22.2% of children homozygous for HbS), and a clinical history of CVA (N = 9, 4.6%) was identified in only children with HbSS disease. Subsequent analyses examined only children with HbSS. Children with a history of CVA performed significantly poorer than children with silent infarcts or no MRI abnormality on most neuropsychological evaluation measures. Children with silent infarcts on MRI performed significantly poorer than children with no MRI abnormality on tests of arithmetic, vocabulary, and visual motor speed and coordination.These results substantiate the importance of careful evaluation, educational planning, and medical intervention for CNS-related complications in children with sickle cell disease.

Duke Scholars

Published In

Pediatrics

EISSN

1098-4275

ISSN

0031-4005

Publication Date

June 1996

Volume

97

Issue

6 Pt 1

Start / End Page

864 / 870

Related Subject Headings

  • Prevalence
  • Pediatrics
  • Neuropsychological Tests
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Intelligence Tests
  • Humans
  • Genotype
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Armstrong, F. D., Thompson, R. J., Wang, W., Zimmerman, R., Pegelow, C. H., Miller, S., … Vass, K. (1996). Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Pediatrics, 97(6 Pt 1), 864–870.
Armstrong, F. D., R. J. Thompson, W. Wang, R. Zimmerman, C. H. Pegelow, S. Miller, F. Moser, J. Bello, A. Hurtig, and K. Vass. “Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease.Pediatrics 97, no. 6 Pt 1 (June 1996): 864–70.
Armstrong FD, Thompson RJ, Wang W, Zimmerman R, Pegelow CH, Miller S, et al. Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Pediatrics. 1996 Jun;97(6 Pt 1):864–70.
Armstrong FD, Thompson RJ, Wang W, Zimmerman R, Pegelow CH, Miller S, Moser F, Bello J, Hurtig A, Vass K. Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Pediatrics. 1996 Jun;97(6 Pt 1):864–870.

Published In

Pediatrics

EISSN

1098-4275

ISSN

0031-4005

Publication Date

June 1996

Volume

97

Issue

6 Pt 1

Start / End Page

864 / 870

Related Subject Headings

  • Prevalence
  • Pediatrics
  • Neuropsychological Tests
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Intelligence Tests
  • Humans
  • Genotype
  • Female