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Valproate reduces excitability by blockage of sodium and potassium conductance.

Publication ,  Journal Article
VanDongen, AM; VanErp, MG; Voskuyl, RA
Published in: Epilepsia
1986

Effects of the antiepileptic drug valproate on sodium and potassium currents in the nodal membrane of peripheral nerve fibers of Xenopus laevis were determined by voltage- and current-clamp experiments. Under voltage-clamp conditions, a reduction of both sodium and potassium conductance (in a ratio of 2:1) was observed. Typically, 2.4 mM (400 mg/L) valproate reduced the sodium current 54% and the potassium current 26%, at a membrane potential of 5 mV. Valproate did not affect the leakage conductance. The reduction of potassium conductance was voltage dependent, being more pronounced at more positive membrane potentials. For the sodium system, a voltage dependency of the blockage could not be established. Under current-clamp conditions, valproate caused a reduction of excitability of nerve membrane: amplitude of the action potential and maximum rate of rise were decreased, whereas threshold potential was increased. The ability to follow high-frequency stimulation was impaired.

Duke Scholars

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

1986

Volume

27

Issue

3

Start / End Page

177 / 182

Location

United States

Related Subject Headings

  • Xenopus
  • Valproic Acid
  • Sodium
  • Potassium
  • Neurology & Neurosurgery
  • Membrane Potentials
  • Epilepsy
  • Electrophysiology
  • Animals
  • 3209 Neurosciences
 

Citation

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ICMJE
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VanDongen, A. M., VanErp, M. G., & Voskuyl, R. A. (1986). Valproate reduces excitability by blockage of sodium and potassium conductance. Epilepsia, 27(3), 177–182. https://doi.org/10.1111/j.1528-1157.1986.tb03525.x
VanDongen, A. M., M. G. VanErp, and R. A. Voskuyl. “Valproate reduces excitability by blockage of sodium and potassium conductance.Epilepsia 27, no. 3 (1986): 177–82. https://doi.org/10.1111/j.1528-1157.1986.tb03525.x.
VanDongen AM, VanErp MG, Voskuyl RA. Valproate reduces excitability by blockage of sodium and potassium conductance. Epilepsia. 1986;27(3):177–82.
VanDongen, A. M., et al. “Valproate reduces excitability by blockage of sodium and potassium conductance.Epilepsia, vol. 27, no. 3, 1986, pp. 177–82. Pubmed, doi:10.1111/j.1528-1157.1986.tb03525.x.
VanDongen AM, VanErp MG, Voskuyl RA. Valproate reduces excitability by blockage of sodium and potassium conductance. Epilepsia. 1986;27(3):177–182.
Journal cover image

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

1986

Volume

27

Issue

3

Start / End Page

177 / 182

Location

United States

Related Subject Headings

  • Xenopus
  • Valproic Acid
  • Sodium
  • Potassium
  • Neurology & Neurosurgery
  • Membrane Potentials
  • Epilepsy
  • Electrophysiology
  • Animals
  • 3209 Neurosciences