Egg oral immunotherapy.


Journal Article (Review)

PURPOSE OF REVIEW: Egg allergy is one of the most common food allergies of childhood and no interventional therapy is currently approved by the Food and Drug Administration. Much recent research has focused on the safety, efficacy, and mechanism of oral immunotherapy (OIT) as a disease-modifying treatment. RECENT FINDINGS: Small pilot studies with varying protocol designs have shown egg OIT to be relatively well tolerated, and efficacy is suggested but not formally demonstrated. At this time, no placebo-controlled randomized trial has been published confirming desensitization and no published study has convincingly demonstrated the development of OIT-induced tolerance to egg. SUMMARY: Egg OIT is a promising modality for providing temporary protection from reactions caused by accidental egg exposure. However, the overall strength of the evidence in favor of egg OIT is limited by small sample sizes and the lack of controls, both of which are important considerations given the spontaneous resolution expected in egg allergy. More high-quality studies are necessary before egg OIT can be recommended as a viable treatment option.

Full Text

Cited Authors

  • Vickery, BP

Published Date

  • June 2012

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 278 - 282

PubMed ID

  • 22488105

Pubmed Central ID

  • 22488105

Electronic International Standard Serial Number (EISSN)

  • 1473-6322

Digital Object Identifier (DOI)

  • 10.1097/ACI.0b013e3283535bae


  • eng

Conference Location

  • United States