Modification of kelly and rice method for synergism tests
In this paper, we present a modified Kelly and Rice method for testing synergism. This approach is consistent with Berenbaum's [1-3] framework for additivity. The delta method  is applied to obtain the estimated variance for the predicted additivity proportion. A Monte Carlo simulation study for the evaluation of the method's performance, i.e., global overall tests for synergism, is also discussed. Kelly and Rice  do not provide a correct test statistic because the variance is underestimated. Hence, the performance of the Kelly-Rice  method is generally anti-conservative, based on the simulation findings. In addition, the overall test of synergism with x 2 (r) from the modified Kelly and Rice method for larger sample sizes is better than that with x 2 (1) from the modified Kelly and Rice method. Copyright © 2002 by Marcel Dekker, Inc.
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