Modification of kelly and rice method for synergism tests


Journal Article

In this paper, we present a modified Kelly and Rice method for testing synergism. This approach is consistent with Berenbaum's [1-3] framework for additivity. The delta method [4] is applied to obtain the estimated variance for the predicted additivity proportion. A Monte Carlo simulation study for the evaluation of the method's performance, i.e., global overall tests for synergism, is also discussed. Kelly and Rice [5] do not provide a correct test statistic because the variance is underestimated. Hence, the performance of the Kelly-Rice [5] method is generally anti-conservative, based on the simulation findings. In addition, the overall test of synergism with x 2 (r) from the modified Kelly and Rice method for larger sample sizes is better than that with x 2 (1) from the modified Kelly and Rice method. Copyright © 2002 by Marcel Dekker, Inc.

Full Text

Cited Authors

  • Wu, M; Woolson, RF

Published Date

  • January 1, 2002

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 1019 - 1030

International Standard Serial Number (ISSN)

  • 0361-0926

Digital Object Identifier (DOI)

  • 10.1081/STA-120004196

Citation Source

  • Scopus