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Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.

Publication ,  Journal Article
Dawson, TM; Arriza, JL; Jaworsky, DE; Borisy, FF; Attramadal, H; Lefkowitz, RJ; Ronnett, GV
Published in: Science
February 5, 1993

beta-Adrenergic receptor kinase (beta ARK) and beta-arrestin function in the homologous or agonist-activated desensitization of G protein-coupled receptors. The isoforms beta ARK-2 and beta-arrestin-2 are highly enriched in and localized to the dendritic knobs and cilia of the olfactory receptor neurons where the initial events of olfactory signal transduction occur. Odorants induce a rapid and transient elevation of adenosine 3',5'-monophosphate (cAMP), which activates a nonspecific cation channel and produces membrane depolarization. Preincubation of rat olfactory cilia with antibodies raised against beta ARK-2 and beta-arrestin-2 increased the odorant-induced elevation of cAMP and attenuated desensitization. These results suggest that beta ARK-2 and beta-arrestin-2 mediate agonist-dependent desensitization in olfaction.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

February 5, 1993

Volume

259

Issue

5096

Start / End Page

825 / 829

Location

United States

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • beta-Adrenergic Receptor Kinases
  • Turbinates
  • Testis
  • Smell
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Rats, Sprague-Dawley
  • Rats
 

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Dawson, T. M., Arriza, J. L., Jaworsky, D. E., Borisy, F. F., Attramadal, H., Lefkowitz, R. J., & Ronnett, G. V. (1993). Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Science, 259(5096), 825–829. https://doi.org/10.1126/science.8381559
Dawson, T. M., J. L. Arriza, D. E. Jaworsky, F. F. Borisy, H. Attramadal, R. J. Lefkowitz, and G. V. Ronnett. “Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.Science 259, no. 5096 (February 5, 1993): 825–29. https://doi.org/10.1126/science.8381559.
Dawson TM, Arriza JL, Jaworsky DE, Borisy FF, Attramadal H, Lefkowitz RJ, et al. Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Science. 1993 Feb 5;259(5096):825–9.
Dawson, T. M., et al. “Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.Science, vol. 259, no. 5096, Feb. 1993, pp. 825–29. Pubmed, doi:10.1126/science.8381559.
Dawson TM, Arriza JL, Jaworsky DE, Borisy FF, Attramadal H, Lefkowitz RJ, Ronnett GV. Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Science. 1993 Feb 5;259(5096):825–829.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

February 5, 1993

Volume

259

Issue

5096

Start / End Page

825 / 829

Location

United States

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • beta-Adrenergic Receptor Kinases
  • Turbinates
  • Testis
  • Smell
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Rats, Sprague-Dawley
  • Rats