A study of cancer cell metastasis using microfluidic transmigration device

Conference Paper

Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy. © 2012 IEEE.

Full Text

Duke Authors

Cited Authors

  • Fu, Y; Vandongen, AMJ; Bourouina, T; Park, WT; Je, MY; Tsai, JM; Kwong, DL; Liu, AQ

Published Date

  • May 7, 2012

Published In

Start / End Page

  • 773 - 776

International Standard Serial Number (ISSN)

  • 1084-6999

International Standard Book Number 13 (ISBN-13)

  • 9781467303248

Digital Object Identifier (DOI)

  • 10.1109/MEMSYS.2012.6170300

Citation Source

  • Scopus