Systemic acquired resistance: turning local infection into global defense.

Published

Journal Article (Review)

Systemic acquired resistance (SAR) is an induced immune mechanism in plants. Unlike vertebrate adaptive immunity, SAR is broad spectrum, with no specificity to the initial infection. An avirulent pathogen causing local programmed cell death can induce SAR through generation of mobile signals, accumulation of the defense hormone salicylic acid, and secretion of the antimicrobial PR (pathogenesis-related) proteins. Consequently, the rest of the plant is protected from secondary infection for a period of weeks to months. SAR can even be passed on to progeny through epigenetic regulation. The Arabidopsis NPR1 (nonexpresser of PR genes 1) protein is a master regulator of SAR. Recent study has shown that salicylic acid directly binds to the NPR1 adaptor proteins NPR3 and NPR4, regulates their interactions with NPR1, and controls NPR1 protein stability. However, how NPR1 interacts with TGA transcription factors to activate defense gene expression is still not well understood. In addition, redox regulators, the mediator complex, WRKY transcription factors, endoplasmic reticulum-resident proteins, and DNA repair proteins play critical roles in SAR.

Full Text

Duke Authors

Cited Authors

  • Fu, ZQ; Dong, X

Published Date

  • January 25, 2013

Published In

Volume / Issue

  • 64 /

Start / End Page

  • 839 - 863

PubMed ID

  • 23373699

Pubmed Central ID

  • 23373699

Electronic International Standard Serial Number (EISSN)

  • 1545-2123

International Standard Serial Number (ISSN)

  • 1543-5008

Digital Object Identifier (DOI)

  • 10.1146/annurev-arplant-042811-105606

Language

  • eng