The continued vital role of electron microscopy in the diagnosis of renal disease/dysfunction.

Journal Article (Journal Article;Review)

Ultrastructural examination remains a crucial diagnostic tool for analysis of renal biopsies, along with light and immunofluorescence microscopy. Several advantages of electron microscopy are the ability to detect most forms of glomerular disease/dysfunction; the ability to examine small, suboptimal, or unusual specimens; and superior resolution that allows the investigator to hunt without preconceived ideas of what he/she is looking for or will find. A few shortcomings must be noted for completeness, including inability to detect disorders without specific ultrastructural signature, biochemical heterogeneity of deposits with similar or identical ultrastructural appearances, and occasional false-negative results in diseases with focal manifestations.

Full Text

Duke Authors

Cited Authors

  • Pavlisko, EN; Howell, DN

Published Date

  • February 2013

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 1 - 8

PubMed ID

  • 23383611

Electronic International Standard Serial Number (EISSN)

  • 1521-0758

Digital Object Identifier (DOI)

  • 10.3109/01913123.2012.670025


  • eng

Conference Location

  • England