The continued vital role of electron microscopy in the diagnosis of renal disease/dysfunction.
Journal Article (Journal Article;Review)
Ultrastructural examination remains a crucial diagnostic tool for analysis of renal biopsies, along with light and immunofluorescence microscopy. Several advantages of electron microscopy are the ability to detect most forms of glomerular disease/dysfunction; the ability to examine small, suboptimal, or unusual specimens; and superior resolution that allows the investigator to hunt without preconceived ideas of what he/she is looking for or will find. A few shortcomings must be noted for completeness, including inability to detect disorders without specific ultrastructural signature, biochemical heterogeneity of deposits with similar or identical ultrastructural appearances, and occasional false-negative results in diseases with focal manifestations.
- Pavlisko, EN; Howell, DN
- February 2013
Volume / Issue
- 37 / 1
Start / End Page
- 1 - 8
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)