The role of intravenous acetaminophen in multimodal pain protocols for perioperative orthopedic patients.

Journal Article (Journal Article;Review)

Multimodal pain management should be considered for all perioperative orthopedic patients. The goal of reducing the amount of perioperative opioid medication given may be achieved by using nonopioid medications, including intravenous acetaminophen. The site of action of acetaminophen is a variety of receptors in the central nervous system. When given intravenously, acetaminophen produces a much higher plasma concentration, which then leads to higher levels in the cerebrospinal fluid. The safety profile and relative lack of systemic adverse reactions make this an attractive analgesic for a wide variety of orthopedic surgical patients. Clinical studies have demonstrated the efficacy and safety of intravenous acetaminophen in elective total hip and knee arthroplasty, knee arthroscopy, lumbar spine surgery, and for acute traumatic limb pain.

Full Text

Duke Authors

Cited Authors

  • Lachiewicz, PF

Published Date

  • February 2013

Published In

Volume / Issue

  • 36 / 2 Suppl

Start / End Page

  • 15 - 19

PubMed ID

  • 23379571

Electronic International Standard Serial Number (EISSN)

  • 1938-2367

Digital Object Identifier (DOI)

  • 10.3928/01477447-20130122-52


  • eng

Conference Location

  • United States