The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis.

Journal Article (Journal Article)

In response to feeding, insulin promotes the uptake of sugar in peripheral tissues and suppresses the production of sugar, a process called gluconeogenesis, in the liver. Recent research has shown that chronic inflammation promotes insulin resistance, and in turn, chronically high glucose levels can drive inflammation. In this issue of the JCI, Stanya et al. investigate the connection between inflammation and glucose homeostasis by analyzing the effect of the antiinflammatory cytokine IL-13. Their results suggest that IL-13 plays an unexpected role in the regulation of glucose homeostasis by modulating gluconeogenesis and may be a useful therapeutic target for treatment of diabetes and metabolic syndrome.

Full Text

Duke Authors

Cited Authors

  • Machado, MV; Yang, Y; Diehl, AM

Published Date

  • January 2013

Published In

Volume / Issue

  • 123 / 1

Start / End Page

  • 115 - 117

PubMed ID

  • 23257364

Pubmed Central ID

  • PMC3533310

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI67238


  • eng

Conference Location

  • United States