Skip to main content

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

Publication ,  Conference
Zhai, G; Teumer, A; Stolk, L; Perry, JRB; Vandenput, L; Coviello, AD; Koster, A; Bell, JT; Bhasin, S; Eriksson, J; Eriksson, A; Ernst, F ...
Published in: PLoS Genet
April 2011

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15 × 10(-36)), SULT2A1 (rs2637125; p =  2.61 × 10(-19)), ARPC1A (rs740160; p =  1.56 × 10(-16)), TRIM4 (rs17277546; p =  4.50 × 10(-11)), BMF (rs7181230; p = 5.44 × 10(-11)), HHEX (rs2497306; p =  4.64 × 10(-9)), BCL2L11 (rs6738028; p = 1.72 × 10(-8)), and CYP2C9 (rs2185570; p = 2.29 × 10(-8)). These genes are associated with type 2 diabetes, lymphoma, actin filament assembly, drug and xenobiotic metabolism, and zinc finger proteins. Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

April 2011

Volume

7

Issue

4

Start / End Page

e1002025

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Transcription Factors
  • Sulfotransferases
  • Proto-Oncogene Proteins
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Membrane Proteins
  • Male
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhai, G., Teumer, A., Stolk, L., Perry, J. R. B., Vandenput, L., Coviello, A. D., … Wallaschofski, H. (2011). Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. In PLoS Genet (Vol. 7, p. e1002025). United States. https://doi.org/10.1371/journal.pgen.1002025
Zhai, Guangju, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster, et al. “Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.” In PLoS Genet, 7:e1002025, 2011. https://doi.org/10.1371/journal.pgen.1002025.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, et al. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. In: PLoS Genet. 2011. p. e1002025.
Zhai, Guangju, et al. “Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.PLoS Genet, vol. 7, no. 4, 2011, p. e1002025. Pubmed, doi:10.1371/journal.pgen.1002025.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, Eriksson A, Ernst F, Ferrucci L, Frayling TM, Glass D, Grundberg E, Haring R, Hedman AK, Hofman A, Kiel DP, Kroemer HK, Liu Y, Lunetta KL, Maggio M, Lorentzon M, Mangino M, Melzer D, Miljkovic I, MuTHER Consortium, Nica A, Penninx BWJH, Vasan RS, Rivadeneira F, Small KS, Soranzo N, Uitterlinden AG, Völzke H, Wilson SG, Xi L, Zhuang WV, Harris TB, Murabito JM, Ohlsson C, Murray A, de Jong FH, Spector TD, Wallaschofski H. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet. 2011. p. e1002025.

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

April 2011

Volume

7

Issue

4

Start / End Page

e1002025

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Transcription Factors
  • Sulfotransferases
  • Proto-Oncogene Proteins
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Membrane Proteins
  • Male
  • Liver