Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.

Published

Journal Article (Review)

Many neuropsychiatric disorders are associated with a strong dysregulation of the immune system, and several have a striking etiology in development as well. Our recent evidence using a rodent model of neonatal Escherichia coli infection has revealed novel insight into the mechanisms underlying cognitive deficits in adulthood, and suggests that the early-life immune history of an individual may be critical to understanding the relative risk of developing later-life mental health disorders in humans. A single neonatal infection programs the function of immune cells within the brain, called microglia, for the life of the rodent such that an adult immune challenge results in exaggerated cytokine production within the brain and associated cognitive deficits. I describe the important role of the immune system, notably microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition.

Full Text

Cited Authors

  • Bilbo, SD

Published Date

  • May 2013

Published In

Volume / Issue

  • 63 / 5

Start / End Page

  • 684 - 691

PubMed ID

  • 23474365

Pubmed Central ID

  • 23474365

Electronic International Standard Serial Number (EISSN)

  • 1095-6867

International Standard Serial Number (ISSN)

  • 0018-506X

Digital Object Identifier (DOI)

  • 10.1016/j.yhbeh.2013.02.017

Language

  • eng