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Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.

Publication ,  Journal Article
Bilbo, SD
Published in: Hormones and behavior
May 2013

Many neuropsychiatric disorders are associated with a strong dysregulation of the immune system, and several have a striking etiology in development as well. Our recent evidence using a rodent model of neonatal Escherichia coli infection has revealed novel insight into the mechanisms underlying cognitive deficits in adulthood, and suggests that the early-life immune history of an individual may be critical to understanding the relative risk of developing later-life mental health disorders in humans. A single neonatal infection programs the function of immune cells within the brain, called microglia, for the life of the rodent such that an adult immune challenge results in exaggerated cytokine production within the brain and associated cognitive deficits. I describe the important role of the immune system, notably microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition.

Duke Scholars

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Published In

Hormones and behavior

DOI

EISSN

1095-6867

ISSN

0018-506X

Publication Date

May 2013

Volume

63

Issue

5

Start / End Page

684 / 691

Related Subject Headings

  • Neurosecretory Systems
  • Neuroimmunomodulation
  • Microglia
  • Learning
  • Immune System
  • Brain
  • Behavioral Science & Comparative Psychology
  • Awards and Prizes
  • Animals, Newborn
  • Animals
 

Citation

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Bilbo, S. D. (2013). Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system. Hormones and Behavior, 63(5), 684–691. https://doi.org/10.1016/j.yhbeh.2013.02.017
Bilbo, Staci D. “Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.Hormones and Behavior 63, no. 5 (May 2013): 684–91. https://doi.org/10.1016/j.yhbeh.2013.02.017.
Bilbo, Staci D. “Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.Hormones and Behavior, vol. 63, no. 5, May 2013, pp. 684–91. Epmc, doi:10.1016/j.yhbeh.2013.02.017.
Journal cover image

Published In

Hormones and behavior

DOI

EISSN

1095-6867

ISSN

0018-506X

Publication Date

May 2013

Volume

63

Issue

5

Start / End Page

684 / 691

Related Subject Headings

  • Neurosecretory Systems
  • Neuroimmunomodulation
  • Microglia
  • Learning
  • Immune System
  • Brain
  • Behavioral Science & Comparative Psychology
  • Awards and Prizes
  • Animals, Newborn
  • Animals