Utility of Intraoperative Frozen Sections during Thyroid Surgery.


Journal Article

Objective. To describe the usefulness of intraoperative frozen section in the diagnosis and treatment of thyroid nodules where fine needle aspirate biopsies have evidence of follicular neoplasm. Study Design. Retrospective case series. Methods. All patients have a fine needle aspirate biopsy, an intraoperative frozen section, and final pathology performed on a thyroid nodule after initiation of the Bethesda System for Reporting Thyroid Cytopathology in 2009 at a single tertiary referral center. Sensitivity, specificity, positive predictive value, and negative predictive value are calculated in order to determine added benefit of frozen section to original fine needle aspirate data. Results. The sensitivity and specificity of the frozen section were 76.9% and 67.9%, respectively, while for the fine needle aspirate were 53.8% and 74.1%, respectively. The positive and negative predictive values for the fine needle aspirates were 25% and 90.9%, respectively, while for the frozen sections were 27.8% and 94.8%, respectively. There were no changes in the operative course as a consequence of the frozen sections. Conclusion. Our data does not support the clinical usefulness of intraoperative frozen section when the fine needle aspirate yields a Bethesda Criteria diagnosis of follicular neoplasm, suspicious for follicular neoplasm, or suspicious for malignancy at our institution.

Full Text

Duke Authors

Cited Authors

  • Kahmke, R; Lee, WT; Puscas, L; Scher, RL; Shealy, MJ; Burch, WM; Esclamado, RM

Published Date

  • 2013

Published In

Volume / Issue

  • 2013 /

Start / End Page

  • 496138 -

PubMed ID

  • 23401692

Pubmed Central ID

  • 23401692

International Standard Serial Number (ISSN)

  • 1687-9201

Digital Object Identifier (DOI)

  • 10.1155/2013/496138


  • eng

Conference Location

  • United States