Reliability and validity of the TIMPSI for infants with spinal muscular atrophy type I.

Journal Article (Journal Article)

PURPOSE: This study examined the reliability and validity of the Test of Infant Motor Performance Screening Items (TIMPSI) in infants with type I spinal muscular atrophy (SMA). METHODS: After training, 12 evaluators scored 4 videos of infants with type I SMA to assess interrater reliability. Intrarater and test-retest reliability was further assessed for 9 evaluators during a SMA type I clinical trial, with 9 evaluators testing a total of 38 infants twice. Relatedness of the TIMPSI score to ability to reach and ventilatory support was also examined. RESULTS: Excellent interrater video score reliability was noted (intraclass correlation coefficient, 0.97-0.98). Intrarater reliability was excellent (intraclass correlation coefficient, 0.91-0.98) and test-retest reliability ranged from r = 0.82 to r = 0.95. The TIMPSI score was related to the ability to reach (P ≤ .05). CONCLUSION: The TIMPSI can reliably be used to assess motor function in infants with type I SMA. In addition, the TIMPSI scores are related to the ability to reach, an important functional skill in children with type I SMA.

Full Text

Duke Authors

Cited Authors

  • Krosschell, KJ; Maczulski, JA; Scott, C; King, W; Hartman, JT; Case, LE; Viazzo-Trussell, D; Wood, J; Roman, CA; Hecker, E; Meffert, M; Léveillé, M; Kienitz, K; Swoboda, KJ; Project Cure SMA Investigators Network,

Published Date

  • 2013

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 140 - 148

PubMed ID

  • 23542189

Pubmed Central ID

  • PMC4381541

Electronic International Standard Serial Number (EISSN)

  • 1538-005X

Digital Object Identifier (DOI)

  • 10.1097/PEP.0b013e31828a205f


  • eng

Conference Location

  • United States