Reliability and validity of the TIMPSI for infants with spinal muscular atrophy type I.


Journal Article

This study examined the reliability and validity of the Test of Infant Motor Performance Screening Items (TIMPSI) in infants with type I spinal muscular atrophy (SMA).After training, 12 evaluators scored 4 videos of infants with type I SMA to assess interrater reliability. Intrarater and test-retest reliability was further assessed for 9 evaluators during a SMA type I clinical trial, with 9 evaluators testing a total of 38 infants twice. Relatedness of the TIMPSI score to ability to reach and ventilatory support was also examined.Excellent interrater video score reliability was noted (intraclass correlation coefficient, 0.97-0.98). Intrarater reliability was excellent (intraclass correlation coefficient, 0.91-0.98) and test-retest reliability ranged from r = 0.82 to r = 0.95. The TIMPSI score was related to the ability to reach (P ≤ .05).The TIMPSI can reliably be used to assess motor function in infants with type I SMA. In addition, the TIMPSI scores are related to the ability to reach, an important functional skill in children with type I SMA.

Full Text

Duke Authors

Cited Authors

  • Krosschell, KJ; Maczulski, JA; Scott, C; King, W; Hartman, JT; Case, LE; Viazzo-Trussell, D; Wood, J; Roman, CA; Hecker, E; Meffert, M; Léveillé, M; Kienitz, K; Swoboda, KJ; Project Cure SMA Investigators Network,

Published Date

  • January 2013

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 140 - 149

PubMed ID

  • 23542189

Pubmed Central ID

  • 23542189

Electronic International Standard Serial Number (EISSN)

  • 1538-005X

International Standard Serial Number (ISSN)

  • 0898-5669

Digital Object Identifier (DOI)

  • 10.1097/PEP.0b013e31828a205f


  • eng