Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates.

Published

Journal Article

OBJECTIVE: To determine the effects of low-dose dopamine on urine output (UOP) in very low birth weight premature neonates. STUDY DESIGN: Retrospective cohort study of all low-dose (3-5 μg kg(-1) per min) dopamine infusions >24-h duration in neonates 1500 g and 32 weeks gestation from August 2009 through September 2011. Linear regression was used to estimate the impact of covariates on UOP. RESULT: We identified 91 episodes of low-dose dopamine use in 65 neonates. Increased UOP occurred in 64% of episodes. Low-dose dopamine use was associated with a 0.6 ml kg(-1) h(-1) increase in UOP (P<0.001) and a 1.3 ml kg(-1)h(-1) increase when baseline UOP was <1.5 ml kg(-1) h(-1) (P<0.001). The improvement remained statistically significant after controlling for medications (diuretics and hydrocortisone) and fluid intake. CONCLUSION: Low-dose dopamine use was associated with increased UOP in very low birth weight neonates.

Full Text

Duke Authors

Cited Authors

  • Crouchley, JL; Smith, PB; Cotten, CM; Hornik, CD; Goldberg, RN; Foreman, JW; Wynn, JL

Published Date

  • August 2013

Published In

Volume / Issue

  • 33 / 8

Start / End Page

  • 619 - 621

PubMed ID

  • 23448938

Pubmed Central ID

  • 23448938

Electronic International Standard Serial Number (EISSN)

  • 1476-5543

Digital Object Identifier (DOI)

  • 10.1038/jp.2013.20

Language

  • eng

Conference Location

  • United States