Striking the target in iron overload disorders.


Journal Article

The liver, a major site of body iron stores, mediates key responses that preserve systemic iron homeostasis. In this issue of the JCI, Guo et al. demonstrate that administration of antisense oligonucleotides that reduce expression of Tmprss6, a hepatic protein that plays an essential role in maintaining iron balance, can attenuate disease severity in mouse models of human iron overload disorders. These data reveal the potential of novel TMPRSS6-targeted therapies for the treatment of clinical conditions such as hereditary hemochromatosis and β-thalassemia.

Full Text

Cited Authors

  • Finberg, KE

Published Date

  • April 2013

Published In

Volume / Issue

  • 123 / 4

Start / End Page

  • 1424 - 1427

PubMed ID

  • 23524962

Pubmed Central ID

  • 23524962

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci68889


  • eng