Light uncages a copper complex to induce nonapoptotic cell death.

Published

Journal Article

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Full Text

Duke Authors

Cited Authors

  • Kumbhar, AA; Franks, AT; Butcher, RJ; Franz, KJ

Published Date

  • March 2013

Published In

Volume / Issue

  • 49 / 24

Start / End Page

  • 2460 - 2462

PubMed ID

  • 23417227

Pubmed Central ID

  • 23417227

Electronic International Standard Serial Number (EISSN)

  • 1364-548X

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/c3cc38927h

Language

  • eng