Light uncages a copper complex to induce nonapoptotic cell death.

Journal Article (Journal Article)

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Franz, Katherine J.

Cited Authors

Kumbhar, AA; Franks, AT; Butcher, RJ; Franz, KJ

Published Date

March 2013

Published In

Chemical Communications

Volume / Issue

49 / 24

Start / End Page

2460 - 2462

PubMed ID

23417227

Electronic International Standard Serial Number (EISSN)

1364-548X

International Standard Serial Number (ISSN)

1359-7345

Digital Object Identifier (DOI)

10.1039/c3cc38927h

Language

eng