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Therapeutic approaches for shankopathies.

Publication ,  Journal Article
Wang, X; Bey, AL; Chung, L; Krystal, AD; Jiang, Y-H
Published in: Dev Neurobiol
February 2014

Despite recent advances in understanding the molecular mechanisms of autism spectrum disorders (ASD), the current treatments for these disorders are mostly focused on behavioral and educational approaches. The considerable clinical and molecular heterogeneity of ASD present a significant challenge to the development of an effective treatment targeting underlying molecular defects. Deficiency of SHANK family genes causing ASD represent an exciting opportunity for developing molecular therapies because of strong genetic evidence for SHANK as causative genes in ASD and the availability of a panel of Shank mutant mouse models. In this article, we review the literature suggesting the potential for developing therapies based on molecular characteristics and discuss several exciting themes that are emerging from studying Shank mutant mice at the molecular level and in terms of synaptic function.

Duke Scholars

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Published In

Dev Neurobiol

DOI

EISSN

1932-846X

Publication Date

February 2014

Volume

74

Issue

2

Start / End Page

123 / 135

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Synaptic Transmission
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Mutation
  • Humans
  • Child Development Disorders, Pervasive
  • Animals
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
 

Citation

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Wang, X., Bey, A. L., Chung, L., Krystal, A. D., & Jiang, Y.-H. (2014). Therapeutic approaches for shankopathies. Dev Neurobiol, 74(2), 123–135. https://doi.org/10.1002/dneu.22084
Wang, Xiaoming, Alexandra L. Bey, Leeyup Chung, Andrew D. Krystal, and Yong-Hui Jiang. “Therapeutic approaches for shankopathies.Dev Neurobiol 74, no. 2 (February 2014): 123–35. https://doi.org/10.1002/dneu.22084.
Wang X, Bey AL, Chung L, Krystal AD, Jiang Y-H. Therapeutic approaches for shankopathies. Dev Neurobiol. 2014 Feb;74(2):123–35.
Wang, Xiaoming, et al. “Therapeutic approaches for shankopathies.Dev Neurobiol, vol. 74, no. 2, Feb. 2014, pp. 123–35. Pubmed, doi:10.1002/dneu.22084.
Wang X, Bey AL, Chung L, Krystal AD, Jiang Y-H. Therapeutic approaches for shankopathies. Dev Neurobiol. 2014 Feb;74(2):123–135.
Journal cover image

Published In

Dev Neurobiol

DOI

EISSN

1932-846X

Publication Date

February 2014

Volume

74

Issue

2

Start / End Page

123 / 135

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Synaptic Transmission
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Mutation
  • Humans
  • Child Development Disorders, Pervasive
  • Animals
  • 3209 Neurosciences
  • 1702 Cognitive Sciences