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Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation.

Publication ,  Journal Article
Peterchev, AV; Goetz, SM; Westin, GG; Luber, B; Lisanby, SH
Published in: Clin Neurophysiol
July 2013

OBJECTIVE: To demonstrate the use of a novel controllable pulse parameter TMS (cTMS) device to characterize human corticospinal tract physiology. METHODS: Motor threshold and input-output (IO) curve of right first dorsal interosseus were determined in 26 and 12 healthy volunteers, respectively, at pulse widths of 30, 60, and 120 μs using a custom-built cTMS device. Strength-duration curve rheobase and time constant were estimated from the motor thresholds. IO slope was estimated from sigmoid functions fitted to the IO data. RESULTS: All procedures were well tolerated with no seizures or other serious adverse events. Increasing pulse width decreased the motor threshold and increased the pulse energy and IO slope. The average strength-duration curve time constant is estimated to be 196 μs, 95% CI [181 μs, 210 μs]. IO slope is inversely correlated with motor threshold both across and within pulse width. A simple quantitative model explains these dependencies. CONCLUSIONS: Our strength-duration time constant estimate compares well to published values and may be more accurate given increased sample size and enhanced methodology. Multiplying the IO slope by the motor threshold may provide a sensitive measure of individual differences in corticospinal tract physiology. SIGNIFICANCE: Pulse parameter control offered by cTMS provides enhanced flexibility that can contribute novel insights in TMS studies.

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Published In

Clin Neurophysiol

DOI

EISSN

1872-8952

Publication Date

July 2013

Volume

124

Issue

7

Start / End Page

1364 / 1372

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Transcranial Magnetic Stimulation
  • Time Factors
  • Neurology & Neurosurgery
  • Motor Cortex
  • Middle Aged
  • Male
  • Humans
  • Female
  • Evoked Potentials, Motor
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Peterchev, A. V., Goetz, S. M., Westin, G. G., Luber, B., & Lisanby, S. H. (2013). Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation. Clin Neurophysiol, 124(7), 1364–1372. https://doi.org/10.1016/j.clinph.2013.01.011
Peterchev, Angel V., Stefan M. Goetz, Gregory G. Westin, Bruce Luber, and Sarah H. Lisanby. “Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation.Clin Neurophysiol 124, no. 7 (July 2013): 1364–72. https://doi.org/10.1016/j.clinph.2013.01.011.
Peterchev AV, Goetz SM, Westin GG, Luber B, Lisanby SH. Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation. Clin Neurophysiol. 2013 Jul;124(7):1364–72.
Peterchev, Angel V., et al. “Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation.Clin Neurophysiol, vol. 124, no. 7, July 2013, pp. 1364–72. Pubmed, doi:10.1016/j.clinph.2013.01.011.
Peterchev AV, Goetz SM, Westin GG, Luber B, Lisanby SH. Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation. Clin Neurophysiol. 2013 Jul;124(7):1364–1372.
Journal cover image

Published In

Clin Neurophysiol

DOI

EISSN

1872-8952

Publication Date

July 2013

Volume

124

Issue

7

Start / End Page

1364 / 1372

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Transcranial Magnetic Stimulation
  • Time Factors
  • Neurology & Neurosurgery
  • Motor Cortex
  • Middle Aged
  • Male
  • Humans
  • Female
  • Evoked Potentials, Motor