Nanopatterned polymer brushes as switchable bioactive interfaces.


Journal Article

We report convenient methods for synthesis of nanopatterned, thermally responsive brushes of poly(N-isopropyl acrylamide) over large areas (e.g., 1 cm(2)) to form model, dynamic, biofunctional surfaces. The new nanopatterned brush structure can be used to control (i) the rate of both nonspecific and biospecific adsorption processes at the polymer-graft-free regions of the substrate, and (ii) the rate of cell detachment. These capabilities have potential implications in a number of areas of biotechnology including biosensing, separations and cell culture.

Full Text

Cited Authors

  • Yu, Q; Shivapooja, P; Johnson, LM; Tizazu, G; Leggett, GJ; López, GP

Published Date

  • May 2013

Published In

Volume / Issue

  • 5 / 9

Start / End Page

  • 3632 - 3637

PubMed ID

  • 23532384

Pubmed Central ID

  • 23532384

Electronic International Standard Serial Number (EISSN)

  • 2040-3372

International Standard Serial Number (ISSN)

  • 2040-3364

Digital Object Identifier (DOI)

  • 10.1039/c3nr00312d


  • eng