Leukemic stem cells: a review.

Journal Article (Review)

A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in mouse models provides several potential therapeutics to target these cells in human patients. Eliminating LSCs should provide an efficient, potentially curative treatment option for leukemia patients.

Full Text

Duke Authors

Cited Authors

  • O'Brien, JA; Rizzieri, DA

Published Date

  • May 2013

Published In

Volume / Issue

  • 31 / 4

Start / End Page

  • 215 - 220

PubMed ID

  • 23473080

Pubmed Central ID

  • 23473080

Electronic International Standard Serial Number (EISSN)

  • 1532-4192

Digital Object Identifier (DOI)

  • 10.3109/07357907.2012.700986


  • eng

Conference Location

  • England