An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes.

Journal Article (Journal Article)

A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes has been achieved via the aminocyclization of reactive unsaturated N-iodoamines, which can be generated in situ from either unsaturated N-chloramines or their amine precursors in a one-pot protocol.

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Duke Authors

Wang, Qiu

Cited Authors

Huang, H-T; Lacy, TC; Błachut, B; Ortiz, GX; Wang, Q

Published Date

April 2013

Published In

Organic Letters

Volume / Issue

15 / 8

Start / End Page

1818 - 1821

PubMed ID

23544433

Pubmed Central ID

23544433

Electronic International Standard Serial Number (EISSN)

1523-7052

International Standard Serial Number (ISSN)

1523-7060

Digital Object Identifier (DOI)

10.1021/ol4003866

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