An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes.
Journal Article (Journal Article)
A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes has been achieved via the aminocyclization of reactive unsaturated N-iodoamines, which can be generated in situ from either unsaturated N-chloramines or their amine precursors in a one-pot protocol.
Full Text
Duke Authors
Cited Authors
- Huang, H-T; Lacy, TC; Błachut, B; Ortiz, GX; Wang, Q
Published Date
- April 2013
Published In
Volume / Issue
- 15 / 8
Start / End Page
- 1818 - 1821
PubMed ID
- 23544433
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7060
Digital Object Identifier (DOI)
- 10.1021/ol4003866
Language
- eng