An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes.

Journal Article (Journal Article)

A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes has been achieved via the aminocyclization of reactive unsaturated N-iodoamines, which can be generated in situ from either unsaturated N-chloramines or their amine precursors in a one-pot protocol.

Full Text

Duke Authors

Cited Authors

  • Huang, H-T; Lacy, TC; BÅ‚achut, B; Ortiz, GX; Wang, Q

Published Date

  • April 2013

Published In

Volume / Issue

  • 15 / 8

Start / End Page

  • 1818 - 1821

PubMed ID

  • 23544433

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol4003866


  • eng