Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.

Journal Article (Journal Article)

Transcranial magnetic stimulation (TMS) can be used to probe cortical function and treat neuropsychiatric illnesses. TMS has demonstrated neuroplastic effects akin to long-term potentiation and long-term depression, and therapeutic applications are in development for post-stroke recovery, Alzheimer's disease, and depression in seniors. Here, we discuss two new directions of TMS research relevant to cerebral aging and cognition. First, we introduce a paradigm for enhancing cognitive reserve, based on our research in sleep deprivation. Second, we discuss the use of magnetic seizure therapy (MST) to spare cognitive functions relative to conventional electroconvulsive therapy, and as a means of providing a more potent antidepressant treatment when subconvulsive TMS has shown modest efficacy in seniors. Whether in the enhancement of cognition as a treatment goal, or in the reduction of amnesia as a side effect, these approaches to the use of TMS and MST merit further exploration regarding their clinical potential.

Full Text

Duke Authors

Cited Authors

  • Luber, B; McClintock, SM; Lisanby, SH

Published Date

  • March 2013

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 87 - 98

PubMed ID

  • 23576892

Pubmed Central ID

  • PMC3622472

Electronic International Standard Serial Number (EISSN)

  • 1958-5969

Digital Object Identifier (DOI)

  • 10.31887/DCNS.2013.15.1/bluber


  • eng

Conference Location

  • England