DICCCOL: dense individualized and common connectivity-based cortical landmarks.

Published

Journal Article

Is there a common structural and functional cortical architecture that can be quantitatively encoded and precisely reproduced across individuals and populations? This question is still largely unanswered due to the vast complexity, variability, and nonlinearity of the cerebral cortex. Here, we hypothesize that the common cortical architecture can be effectively represented by group-wise consistent structural fiber connections and take a novel data-driven approach to explore the cortical architecture. We report a dense and consistent map of 358 cortical landmarks, named Dense Individualized and Common Connectivity-based Cortical Landmarks (DICCCOLs). Each DICCCOL is defined by group-wise consistent white-matter fiber connection patterns derived from diffusion tensor imaging (DTI) data. Our results have shown that these 358 landmarks are remarkably reproducible over more than one hundred human brains and possess accurate intrinsically established structural and functional cross-subject correspondences validated by large-scale functional magnetic resonance imaging data. In particular, these 358 cortical landmarks can be accurately and efficiently predicted in a new single brain with DTI data. Thus, this set of 358 DICCCOL landmarks comprehensively encodes the common structural and functional cortical architectures, providing opportunities for many applications in brain science including mapping human brain connectomes, as demonstrated in this work.

Full Text

Duke Authors

Cited Authors

  • Zhu, D; Li, K; Guo, L; Jiang, X; Zhang, T; Zhang, D; Chen, H; Deng, F; Faraco, C; Jin, C; Wee, C-Y; Yuan, Y; Lv, P; Yin, Y; Hu, X; Duan, L; Hu, X; Han, J; Wang, L; Shen, D; Miller, LS; Li, L; Liu, T

Published Date

  • April 2013

Published In

Volume / Issue

  • 23 / 4

Start / End Page

  • 786 - 800

PubMed ID

  • 22490548

Pubmed Central ID

  • 22490548

Electronic International Standard Serial Number (EISSN)

  • 1460-2199

International Standard Serial Number (ISSN)

  • 1047-3211

Digital Object Identifier (DOI)

  • 10.1093/cercor/bhs072

Language

  • eng