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Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies.

Publication ,  Journal Article
Sieh, W; Salvador, S; McGuire, V; Weber, RP; Terry, KL; Rossing, MA; Risch, H; Wu, AH; Webb, PM; Moysich, K; Doherty, JA; Felberg, A ...
Published in: Int J Epidemiol
April 2013

BACKGROUND: Tubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association between tubal ligation and ovarian cancer subtypes. METHODS: We pooled primary data from 13 population-based case-control studies, including 10,157 patients with ovarian cancer (7942 invasive; 2215 borderline) and 13,904 control women. Invasive cases were analysed by histological type, grade and stage, and borderline cases were analysed by histological type. Pooled odds ratios were estimated using conditional logistic regression to match on site, race/ethnicity and age categories, and to adjust for age, oral contraceptive use duration and number of full-term births. RESULTS: Tubal ligation was associated with significantly reduced risks of invasive serous (OR, 0.81; 95% CI, 0.74-0.89; P < 0.001), endometrioid (OR, 0.48; 95% CI, 0.40-0.59; P < 0.001), clear cell (OR, 0.52; 95% CI, 0.40-0.67; P < 0.001) and mucinous (OR, 0.68; 95% CI, 0.52-0.89; P = 0.005) cancers. The magnitude of risk reduction was significantly greater for invasive endometrioid (P < 0.0001) and clear cell (P = 0.0018) than for serous cancer. No significant associations were found with borderline serous or mucinous tumours. CONCLUSIONS: We found that the protective effects of tubal ligation on ovarian cancer risk were subtype-specific. These findings provide insights into distinct aetiologies of ovarian cancer subtypes and mechanisms underlying the protective effects of tubal ligation.

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Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

April 2013

Volume

42

Issue

2

Start / End Page

579 / 589

Location

England

Related Subject Headings

  • Young Adult
  • Sterilization, Tubal
  • Risk Factors
  • Registries
  • Ovarian Neoplasms
  • Odds Ratio
  • Middle Aged
  • Logistic Models
  • Humans
  • Female
 

Citation

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Sieh, W., Salvador, S., McGuire, V., Weber, R. P., Terry, K. L., Rossing, M. A., … Ovarian Cancer Association Consortium, . (2013). Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies. Int J Epidemiol, 42(2), 579–589. https://doi.org/10.1093/ije/dyt042
Sieh, Weiva, Shannon Salvador, Valerie McGuire, Rachel Palmieri Weber, Kathryn L. Terry, Mary Anne Rossing, Harvey Risch, et al. “Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies.Int J Epidemiol 42, no. 2 (April 2013): 579–89. https://doi.org/10.1093/ije/dyt042.
Sieh W, Salvador S, McGuire V, Weber RP, Terry KL, Rossing MA, et al. Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies. Int J Epidemiol. 2013 Apr;42(2):579–89.
Sieh, Weiva, et al. “Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies.Int J Epidemiol, vol. 42, no. 2, Apr. 2013, pp. 579–89. Pubmed, doi:10.1093/ije/dyt042.
Sieh W, Salvador S, McGuire V, Weber RP, Terry KL, Rossing MA, Risch H, Wu AH, Webb PM, Moysich K, Doherty JA, Felberg A, Miller D, Jordan SJ, Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Study Group, Goodman MT, Lurie G, Chang-Claude J, Rudolph A, Kjær SK, Jensen A, Høgdall E, Bandera EV, Olson SH, King MG, Rodriguez-Rodriguez L, Kiemeney LA, Marees T, Massuger LF, van Altena AM, Ness RB, Cramer DW, Pike MC, Pearce CL, Berchuck A, Schildkraut JM, Whittemore AS, Ovarian Cancer Association Consortium. Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies. Int J Epidemiol. 2013 Apr;42(2):579–589.
Journal cover image

Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

April 2013

Volume

42

Issue

2

Start / End Page

579 / 589

Location

England

Related Subject Headings

  • Young Adult
  • Sterilization, Tubal
  • Risk Factors
  • Registries
  • Ovarian Neoplasms
  • Odds Ratio
  • Middle Aged
  • Logistic Models
  • Humans
  • Female