Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.

Journal Article (Journal Article;Review)

Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. Although IDH1 mutations confer a unique genotype that has been associated with a favorable prognosis, the role of the mutated IDH1 enzyme and its metabolites in tumor initiation and maintenance remains unresolved. However, given that IDH1 mutations are homogeneously expressed and are limited solely to tumor tissue, targeting this mutation could potentially yield novel treatment strategies for patients with glioblastoma multiforme.

Full Text

Duke Authors

Cited Authors

  • Hodges, TR; Choi, BD; Bigner, DD; Yan, H; Sampson, JH

Published Date

  • June 2013

Published In

Volume / Issue

  • 118 / 6

Start / End Page

  • 1176 - 1180

PubMed ID

  • 23581583

Pubmed Central ID

  • PMC3672384

Electronic International Standard Serial Number (EISSN)

  • 1933-0693

Digital Object Identifier (DOI)

  • 10.3171/2013.3.JNS122282


  • eng

Conference Location

  • United States