Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.
Publication
, Journal Article
Hodges, TR; Choi, BD; Bigner, DD; Yan, H; Sampson, JH
Published in: J Neurosurg
June 2013
Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. Although IDH1 mutations confer a unique genotype that has been associated with a favorable prognosis, the role of the mutated IDH1 enzyme and its metabolites in tumor initiation and maintenance remains unresolved. However, given that IDH1 mutations are homogeneously expressed and are limited solely to tumor tissue, targeting this mutation could potentially yield novel treatment strategies for patients with glioblastoma multiforme.
Duke Scholars
Published In
J Neurosurg
DOI
EISSN
1933-0693
Publication Date
June 2013
Volume
118
Issue
6
Start / End Page
1176 / 1180
Location
United States
Related Subject Headings
- Prognosis
- Neurology & Neurosurgery
- Mutation
- Isocitrate Dehydrogenase
- Humans
- Glioma
- Glioblastoma
- Genotype
- Genetic Testing
- Gene Expression Regulation, Neoplastic
Citation
APA
Chicago
ICMJE
MLA
NLM
Hodges, T. R., Choi, B. D., Bigner, D. D., Yan, H., & Sampson, J. H. (2013). Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review. J Neurosurg, 118(6), 1176–1180. https://doi.org/10.3171/2013.3.JNS122282
Hodges, Tiffany R., Bryan D. Choi, Darell D. Bigner, Hai Yan, and John H. Sampson. “Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.” J Neurosurg 118, no. 6 (June 2013): 1176–80. https://doi.org/10.3171/2013.3.JNS122282.
Hodges TR, Choi BD, Bigner DD, Yan H, Sampson JH. Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review. J Neurosurg. 2013 Jun;118(6):1176–80.
Hodges, Tiffany R., et al. “Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.” J Neurosurg, vol. 118, no. 6, June 2013, pp. 1176–80. Pubmed, doi:10.3171/2013.3.JNS122282.
Hodges TR, Choi BD, Bigner DD, Yan H, Sampson JH. Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review. J Neurosurg. 2013 Jun;118(6):1176–1180.
Published In
J Neurosurg
DOI
EISSN
1933-0693
Publication Date
June 2013
Volume
118
Issue
6
Start / End Page
1176 / 1180
Location
United States
Related Subject Headings
- Prognosis
- Neurology & Neurosurgery
- Mutation
- Isocitrate Dehydrogenase
- Humans
- Glioma
- Glioblastoma
- Genotype
- Genetic Testing
- Gene Expression Regulation, Neoplastic