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Cardiohepatic interactions in heart failure: an overview and clinical implications.

Publication ,  Journal Article
Samsky, MD; Patel, CB; DeWald, TA; Smith, AD; Felker, GM; Rogers, JG; Hernandez, AF
Published in: J Am Coll Cardiol
June 18, 2013

Heart failure (HF) is a major public health problem leading to frequent hospitalizations, impaired quality of life, and shortened life expectancy. Heart failure leads to a chronic inability to meet metabolic requirements of end organs or skeletal muscle. Current literature lacks comprehensive descriptions of HF effects on hepatic function. In this review paper, we summarize the literature that is available in hopes of highlighting the key differences in clinical presentation, histological findings, and biochemical profiles of patients who present with both acute and chronic liver injury secondary to HF. We further discuss the use of liver function tests as prognostic markers in patients with HF, as well as the implications of liver injury on drug metabolism in this patient population. Finally, we provide recommendations regarding the management of both types of liver injury in HF patients.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

June 18, 2013

Volume

61

Issue

24

Start / End Page

2397 / 2405

Location

United States

Related Subject Headings

  • gamma-Glutamyltransferase
  • Treatment Outcome
  • Prognosis
  • Liver Function Tests
  • Liver Diseases
  • Liver
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Cardiology
 

Citation

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Samsky, M. D., Patel, C. B., DeWald, T. A., Smith, A. D., Felker, G. M., Rogers, J. G., & Hernandez, A. F. (2013). Cardiohepatic interactions in heart failure: an overview and clinical implications. J Am Coll Cardiol, 61(24), 2397–2405. https://doi.org/10.1016/j.jacc.2013.03.042
Samsky, Marc D., Chetan B. Patel, Tracy A. DeWald, Alastair D. Smith, G Michael Felker, Joseph G. Rogers, and Adrian F. Hernandez. “Cardiohepatic interactions in heart failure: an overview and clinical implications.J Am Coll Cardiol 61, no. 24 (June 18, 2013): 2397–2405. https://doi.org/10.1016/j.jacc.2013.03.042.
Samsky MD, Patel CB, DeWald TA, Smith AD, Felker GM, Rogers JG, et al. Cardiohepatic interactions in heart failure: an overview and clinical implications. J Am Coll Cardiol. 2013 Jun 18;61(24):2397–405.
Samsky, Marc D., et al. “Cardiohepatic interactions in heart failure: an overview and clinical implications.J Am Coll Cardiol, vol. 61, no. 24, June 2013, pp. 2397–405. Pubmed, doi:10.1016/j.jacc.2013.03.042.
Samsky MD, Patel CB, DeWald TA, Smith AD, Felker GM, Rogers JG, Hernandez AF. Cardiohepatic interactions in heart failure: an overview and clinical implications. J Am Coll Cardiol. 2013 Jun 18;61(24):2397–2405.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

June 18, 2013

Volume

61

Issue

24

Start / End Page

2397 / 2405

Location

United States

Related Subject Headings

  • gamma-Glutamyltransferase
  • Treatment Outcome
  • Prognosis
  • Liver Function Tests
  • Liver Diseases
  • Liver
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Cardiology