Biomarkers for smoking cessation.

Journal Article (Journal Article;Review)

One way to enhance therapeutic development is through the identification and development of evaluative tools such as biomarkers. This review focuses on putative diagnostic, pharmacodynamic, and predictive biomarkers for smoking cessation. These types of biomarkers may be used to more accurately diagnose a disease, personalize treatment, identify novel targets for drug discovery, and enhance the efficiency of drug development. Promising biomarkers are presented across a range of approaches including metabolism, genetics, and neuroimaging. A preclinical viewpoint is also offered, as are analytical considerations and a regulatory perspective summarizing a pathway toward biomarker qualification.

Full Text

Duke Authors

Cited Authors

  • Bough, KJ; Lerman, C; Rose, JE; McClernon, FJ; Kenny, PJ; Tyndale, RF; David, SP; Stein, EA; Uhl, GR; Conti, DV; Green, C; Amur, S

Published Date

  • June 2013

Published In

Volume / Issue

  • 93 / 6

Start / End Page

  • 526 - 538

PubMed ID

  • 23588313

Pubmed Central ID

  • PMC3772534

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2013.57


  • eng

Conference Location

  • United States