Effect of vitamin D supplementation on blood pressure in blacks.

Published

Journal Article

Blacks have significantly higher rates of hypertension than whites, and lower circulating levels of 25-hydroxyvitamin D. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on blood pressure in blacks. During 2 winters from 2008 to 2010, 283 blacks (median age, 51 years) were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 international units of cholecalciferol per day. At baseline, 3 months, and 6 months, systolic and diastolic pressure and 25-hydroxyvitamin D were measured. The 3-month follow-up was completed in 250 (88%) participants. The difference in systolic pressure between baseline and 3 months was +1.7 mm Hg for those receiving placebo, -0.66 mm Hg for 1000 U/d, -3.4 mm Hg for 2000 U/d, and -4.0 mm Hg for 4000 U/d of cholecalciferol (-1.4 mm Hg for each additional 1000 U/d of cholecalciferol; P=0.04). For each 1-ng/mL increase in plasma 25-hydroxyvitamin D, there was a significant 0.2-mm Hg reduction in systolic pressure (P=0.02). There was no effect of cholecalciferol supplementation on diastolic pressure (P=0.37). Within an unselected population of blacks, 3 months of oral vitamin D3 supplementation significantly, yet modestly, lowered systolic pressure. Future trials of vitamin D supplementation on blood pressure are needed to confirm these promising results, particularly among blacks, a population for whom vitamin D deficiency may play a more specific mechanistic role in the pathogenesis of hypertension.

Full Text

Duke Authors

Cited Authors

  • Forman, JP; Scott, JB; Ng, K; Drake, BF; Suarez, EG; Hayden, DL; Bennett, GG; Chandler, PD; Hollis, BW; Emmons, KM; Giovannucci, EL; Fuchs, CS; Chan, AT

Published Date

  • April 2013

Published In

Volume / Issue

  • 61 / 4

Start / End Page

  • 779 - 785

PubMed ID

  • 23487599

Pubmed Central ID

  • 23487599

Electronic International Standard Serial Number (EISSN)

  • 1524-4563

International Standard Serial Number (ISSN)

  • 0194-911X

Digital Object Identifier (DOI)

  • 10.1161/HYPERTENSIONAHA.111.00659

Language

  • eng