Skip to main content
Journal cover image

Effect of pharmacologic increases in afterload on left ventricular rotation and strain in a rabbit model.

Publication ,  Journal Article
Ho, JK; Zhou, W; Ashraf, M; Swaminathan, M; Sahn, D; Mahajan, A
Published in: J Am Soc Echocardiogr
June 2013

BACKGROUND: Assessment of left ventricular rotational mechanics and myocardial deformation may provide new insight into both systolic and diastolic function. However, the effects of increasing afterload on these measures of cardiac function are poorly understood. The aim of this study was to identify the changes in left ventricular function and rotational mechanics during increasing pharmacologic afterload. METHODS: In 14 anesthetized rabbits, two-dimensional speckle-tracking echocardiographic images and left ventricular pressure-volume loops were acquired at baseline and during norepinephrine, phenylephrine, and vasopressin infusion at increasing doses. Maximal ventricular elastance, arterial elastance, ventricular-arterial coupling, dP/dt, the time constant of relaxation, and other hemodynamic parameters were determined. RESULTS: An increase in dP/dtmax with norepinephrine and phenylephrine and a decrease with vasopressin at escalating doses were detected. Ventricular-arterial coupling was preserved with norepinephrine and phenylephrine but decreased with vasopressin (P < .05). Apical rotation, rotational rate, and strain were preserved during the norepinephrine and phenylephrine infusions but were reduced with vasopressin (P < .05). Apical rotation and circumferential strain were significantly correlated with both ventricular-arterial coupling (r = 0.84 and r = 0.81) and dP/dtmax (r = -0.81 and r = -0.77). High-dose vasopressin decreased the diastolic time constant of relaxation and dP/dtmin while reducing apical untwisting rate. CONCLUSIONS: Pharmacologic increases in afterload with vasopressin resulted in greater derangements in ventricular-arterial coupling and cardiac performance compared with norepinephrine and phenylephrine. Rotation and strain correlated well with invasively determined measures and can be used to assess afterload-induced alteration in cardiac function.

Duke Scholars

Published In

J Am Soc Echocardiogr

DOI

EISSN

1097-6795

Publication Date

June 2013

Volume

26

Issue

6

Start / End Page

674 / 682

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Vasopressins
  • Rotation
  • Reproducibility of Results
  • Rabbits
  • Phenylephrine
  • Norepinephrine
  • Linear Models
  • Hemodynamics
  • Echocardiography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ho, J. K., Zhou, W., Ashraf, M., Swaminathan, M., Sahn, D., & Mahajan, A. (2013). Effect of pharmacologic increases in afterload on left ventricular rotation and strain in a rabbit model. J Am Soc Echocardiogr, 26(6), 674–682. https://doi.org/10.1016/j.echo.2013.03.010
Ho, Jonathan K., Wei Zhou, Muhammad Ashraf, Madhav Swaminathan, David Sahn, and Aman Mahajan. “Effect of pharmacologic increases in afterload on left ventricular rotation and strain in a rabbit model.J Am Soc Echocardiogr 26, no. 6 (June 2013): 674–82. https://doi.org/10.1016/j.echo.2013.03.010.
Ho JK, Zhou W, Ashraf M, Swaminathan M, Sahn D, Mahajan A. Effect of pharmacologic increases in afterload on left ventricular rotation and strain in a rabbit model. J Am Soc Echocardiogr. 2013 Jun;26(6):674–82.
Ho, Jonathan K., et al. “Effect of pharmacologic increases in afterload on left ventricular rotation and strain in a rabbit model.J Am Soc Echocardiogr, vol. 26, no. 6, June 2013, pp. 674–82. Pubmed, doi:10.1016/j.echo.2013.03.010.
Ho JK, Zhou W, Ashraf M, Swaminathan M, Sahn D, Mahajan A. Effect of pharmacologic increases in afterload on left ventricular rotation and strain in a rabbit model. J Am Soc Echocardiogr. 2013 Jun;26(6):674–682.
Journal cover image

Published In

J Am Soc Echocardiogr

DOI

EISSN

1097-6795

Publication Date

June 2013

Volume

26

Issue

6

Start / End Page

674 / 682

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Vasopressins
  • Rotation
  • Reproducibility of Results
  • Rabbits
  • Phenylephrine
  • Norepinephrine
  • Linear Models
  • Hemodynamics
  • Echocardiography