Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
Journal Article (Journal Article;Multicenter Study)
Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The CREAM consortium conducted genome-wide meta-analyses, including 37,382 individuals from 27 studies of European ancestry and 8,376 from 5 Asian cohorts. We identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians. Combined analysis identified 8 additional associated loci. The new loci include candidate genes with functions in neurotransmission (GRIA4), ion transport (KCNQ5), retinoic acid metabolism (RDH5), extracellular matrix remodeling (LAMA2 and BMP2) and eye development (SIX6 and PRSS56). We also confirmed previously reported associations with GJD2 and RASGRF1. Risk score analysis using associated SNPs showed a tenfold increased risk of myopia for individuals carrying the highest genetic load. Our results, based on a large meta-analysis across independent multiancestry studies, considerably advance understanding of the mechanisms involved in refractive error and myopia.
Full Text
Duke Authors
Cited Authors
- Verhoeven, VJM; Hysi, PG; Wojciechowski, R; Fan, Q; Guggenheim, JA; Höhn, R; MacGregor, S; Hewitt, AW; Nag, A; Cheng, C-Y; Yonova-Doing, E; Zhou, X; Ikram, MK; Buitendijk, GHS; McMahon, G; Kemp, JP; Pourcain, BS; Simpson, CL; Mäkelä, K-M; Lehtimäki, T; Kähönen, M; Paterson, AD; Hosseini, SM; Wong, HS; Xu, L; Jonas, JB; Pärssinen, O; Wedenoja, J; Yip, SP; Ho, DWH; Pang, CP; Chen, LJ; Burdon, KP; Craig, JE; Klein, BEK; Klein, R; Haller, T; Metspalu, A; Khor, C-C; Tai, E-S; Aung, T; Vithana, E; Tay, W-T; Barathi, VA; Consortium for Refractive Error and Myopia (CREAM), ; Chen, P; Li, R; Liao, J; Zheng, Y; Ong, RT; Döring, A; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, ; Evans, DM; Timpson, NJ; Verkerk, AJMH; Meitinger, T; Raitakari, O; Hawthorne, F; Spector, TD; Karssen, LC; Pirastu, M; Murgia, F; Ang, W; Wellcome Trust Case Control Consortium 2 (WTCCC2), ; Mishra, A; Montgomery, GW; Pennell, CE; Cumberland, PM; Cotlarciuc, I; Mitchell, P; Wang, JJ; Schache, M; Janmahasatian, S; Igo, RP; Lass, JH; Chew, E; Iyengar, SK; Fuchs' Genetics Multi-Center Study Group, ; Gorgels, TGMF; Rudan, I; Hayward, C; Wright, AF; Polasek, O; Vatavuk, Z; Wilson, JF; Fleck, B; Zeller, T; Mirshahi, A; Müller, C; Uitterlinden, AG; Rivadeneira, F; Vingerling, JR; Hofman, A; Oostra, BA; Amin, N; Bergen, AAB; Teo, Y-Y; Rahi, JS; Vitart, V; Williams, C; Baird, PN; Wong, T-Y; Oexle, K; Pfeiffer, N; Mackey, DA; Young, TL; van Duijn, CM; Saw, S-M; Bailey-Wilson, JE; Stambolian, D; Klaver, CC; Hammond, CJ
Published Date
- March 2013
Published In
Volume / Issue
- 45 / 3
Start / End Page
- 314 - 318
PubMed ID
- 23396134
Pubmed Central ID
- PMC3740568
Electronic International Standard Serial Number (EISSN)
- 1546-1718
Digital Object Identifier (DOI)
- 10.1038/ng.2554
Language
- eng
Conference Location
- United States