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Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches.

Publication ,  Journal Article
Subherwal, S; Ohman, EM; Mahaffey, KW; Rao, SV; Alexander, JH; Wang, TY; Alexander, KP; Hasselblad, V; Roe, MT
Published in: Am Heart J
May 2013

With the large number of antithrombotic therapies available and under investigation for the treatment of non-ST-segment elevation acute coronary syndromes (NSTE ACS), practice guidelines now stress the importance of selecting an antithrombotic strategy according to the efficacy and safety profiles of the chosen agent. Contemporary trials have incorporated bleeding along with ischemic end points into a composite end point commonly referred to as net clinical benefit, which allows for simultaneous evaluation of the differences between benefit and harm for an investigational antithrombotic therapy. However, incorporating major bleeding into a composite end point that includes ischemic events is not warranted and is associated with many pitfalls. In this article, we discuss the validity of combining efficacy and safety end points to form a net clinical benefit composite end point with the traditional time-to-event analysis for trials evaluating antithrombotic therapies for NSTE ACS. We describe alternative statistical approaches for concurrent assessment of the safety and efficacy of antithrombotic therapies used to treat patients with NSTE ACS.

Duke Scholars

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2013

Volume

165

Issue

5

Start / End Page

644 / 654.e1

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Platelet Aggregation Inhibitors
  • Incidence
  • Humans
  • Hemorrhage
  • Electrocardiography
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Anticoagulants
 

Citation

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Subherwal, S., Ohman, E. M., Mahaffey, K. W., Rao, S. V., Alexander, J. H., Wang, T. Y., … Roe, M. T. (2013). Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches. Am Heart J, 165(5), 644-654.e1. https://doi.org/10.1016/j.ahj.2012.11.012
Subherwal, Sumeet, E Magnus Ohman, Kenneth W. Mahaffey, Sunil V. Rao, John H. Alexander, Tracy Y. Wang, Karen P. Alexander, Vic Hasselblad, and Matthew T. Roe. “Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches.Am Heart J 165, no. 5 (May 2013): 644-654.e1. https://doi.org/10.1016/j.ahj.2012.11.012.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2013

Volume

165

Issue

5

Start / End Page

644 / 654.e1

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Platelet Aggregation Inhibitors
  • Incidence
  • Humans
  • Hemorrhage
  • Electrocardiography
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Anticoagulants