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Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants.

Publication ,  Journal Article
Wynn, JL; Li, L; Cotten, CM; Phelps, DL; Shankaran, S; Goldberg, RN; Carlo, WA; Van Meurs, K; Das, A; Vohr, BR; Higgins, RD; Stoll, BJ; D'Angio, CT
Published in: J Perinatol
August 2013

OBJECTIVE: Sepsis in older children and adults modifies immune system function. We compared serotype-specific antibody responses to heptavalent pneumococcal conjugate vaccine (PCV7) in very low birth weight infants (<1500 g,VLBWs) with and without blood stream infection (BSI) during their birth hospitalization. STUDY DESIGN: Retrospective analysis of prospectively collected data for the Neonatal Research Network study of PCV7 responses among VLBWs. Infants received PCV7 at 2, 4 and 6 months after birth with blood drawn 4 to 6 weeks after third dose. Serotype antibodies were compared between infants with or without a history of BSI. Regression models were constructed with BW groups and other confounding factors identified in the primary study. RESULT: In all, 244 infants completed the vaccine series and had serum antibody available; 82 had BSI. After adjustment, BSI was not associated with reduced odds of serum antibody 0.35 μg ml(-1). CONCLUSION: BSI was not associated with reduced odds of World Health Organization-defined protective PCV7 responses in VLBWs.

Duke Scholars

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

August 2013

Volume

33

Issue

8

Start / End Page

613 / 618

Location

United States

Related Subject Headings

  • Sepsis
  • Retrospective Studies
  • Pneumococcal Vaccines
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Newborn
  • Humans
  • Heptavalent Pneumococcal Conjugate Vaccine
 

Citation

APA
Chicago
ICMJE
MLA
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Wynn, J. L., Li, L., Cotten, C. M., Phelps, D. L., Shankaran, S., Goldberg, R. N., … D’Angio, C. T. (2013). Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants. J Perinatol, 33(8), 613–618. https://doi.org/10.1038/jp.2013.5
Wynn, J. L., L. Li, C. M. Cotten, D. L. Phelps, S. Shankaran, R. N. Goldberg, W. A. Carlo, et al. “Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants.J Perinatol 33, no. 8 (August 2013): 613–18. https://doi.org/10.1038/jp.2013.5.
Wynn JL, Li L, Cotten CM, Phelps DL, Shankaran S, Goldberg RN, et al. Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants. J Perinatol. 2013 Aug;33(8):613–8.
Wynn, J. L., et al. “Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants.J Perinatol, vol. 33, no. 8, Aug. 2013, pp. 613–18. Pubmed, doi:10.1038/jp.2013.5.
Wynn JL, Li L, Cotten CM, Phelps DL, Shankaran S, Goldberg RN, Carlo WA, Van Meurs K, Das A, Vohr BR, Higgins RD, Stoll BJ, D’Angio CT. Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants. J Perinatol. 2013 Aug;33(8):613–618.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

August 2013

Volume

33

Issue

8

Start / End Page

613 / 618

Location

United States

Related Subject Headings

  • Sepsis
  • Retrospective Studies
  • Pneumococcal Vaccines
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Newborn
  • Humans
  • Heptavalent Pneumococcal Conjugate Vaccine