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Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births.

Publication ,  Journal Article
Boghossian, NS; Page, GP; Bell, EF; Stoll, BJ; Murray, JC; Cotten, CM; Shankaran, S; Walsh, MC; Laptook, AR; Newman, NS; Hale, EC; Das, A ...
Published in: J Pediatr
June 2013

OBJECTIVES: To describe and compare the incidence of late-onset sepsis (LOS) and demographic and clinical characteristics associated with LOS in very low birth weight (VLBW) infants from singleton and multiple births, and to examine the heritability of susceptibility to LOS among VLBW twins by comparing same-sex and unlike-sex twin pairs. STUDY DESIGN: The study group comprised infants with birth weight 401-1500 g seen at clinical centers of the Eunice Kennedy Shriver National Institute of Child and Human Development Neonatal Research Network between 2002 and 2008. Only the first episode of LOS was included in our analysis. Stepwise logistic regression models were fitted separately for singleton and multiple pregnancies to examine the maternal and neonatal factors associated with LOS. LOS due solely to gram-negative bacteria in singleton and multiple pregnancies was also examined in separate models. The heritability of LOS was estimated by examining the concordance of LOS in twins from same-sex and unlike-sex pairs. RESULTS: LOS occurred in 25.0% (3797 of 15,178) of singleton and 22.6% (1196 of 5294) of multiple-birth VLBW infants. Coagulase-negative staphylococci were the most common infecting organisms, accounting for 53.2% of all LOS episodes in singletons and 49.2% in multiples. Escherichia coli and Klebsiella species were the most commonly isolated gram-negative organisms, and Candida albicans was the most commonly isolated fungus. Concordance of LOS did not differ significantly between same-sex and unlike-sex twin pairs. CONCLUSION: LOS remains a common problem in VLBW infants. The incidence of LOS is similar for singleton and multiple-birth infants. The similar concordance of LOS in same-sex and unlike-sex twin pairs provides no evidence that susceptibility to LOS among VLBW infants is genetically determined.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

June 2013

Volume

162

Issue

6

Start / End Page

1120 / 1124.e1

Location

United States

Related Subject Headings

  • Sepsis
  • Risk Factors
  • Pediatrics
  • Multiple Birth Offspring
  • Male
  • Logistic Models
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Newborn
  • Incidence
 

Citation

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Boghossian, N. S., Page, G. P., Bell, E. F., Stoll, B. J., Murray, J. C., Cotten, C. M., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2013). Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. J Pediatr, 162(6), 1120-1124.e1. https://doi.org/10.1016/j.jpeds.2012.11.089
Boghossian, Nansi S., Grier P. Page, Edward F. Bell, Barbara J. Stoll, Jeffrey C. Murray, C Michael Cotten, Seetha Shankaran, et al. “Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births.J Pediatr 162, no. 6 (June 2013): 1120-1124.e1. https://doi.org/10.1016/j.jpeds.2012.11.089.
Boghossian NS, Page GP, Bell EF, Stoll BJ, Murray JC, Cotten CM, et al. Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. J Pediatr. 2013 Jun;162(6):1120-1124.e1.
Boghossian, Nansi S., et al. “Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births.J Pediatr, vol. 162, no. 6, June 2013, pp. 1120-1124.e1. Pubmed, doi:10.1016/j.jpeds.2012.11.089.
Boghossian NS, Page GP, Bell EF, Stoll BJ, Murray JC, Cotten CM, Shankaran S, Walsh MC, Laptook AR, Newman NS, Hale EC, McDonald SA, Das A, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. J Pediatr. 2013 Jun;162(6):1120-1124.e1.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

June 2013

Volume

162

Issue

6

Start / End Page

1120 / 1124.e1

Location

United States

Related Subject Headings

  • Sepsis
  • Risk Factors
  • Pediatrics
  • Multiple Birth Offspring
  • Male
  • Logistic Models
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Newborn
  • Incidence