Radiation therapy in anal and rectal cancer.

Journal Article (Journal Article;Review)

Historically, squamous cell carcinoma of the anal canal was treated with abdominoperineal resection. Nigro discovered that radiation therapy combined with 5-fluorouracil and mitomycin resulted in high rates of local control and colostomy-free and overall survival without surgical intervention. Recent advances include the integration of PET into staging, radiation treatment planning, disease monitoring, and the use of intensity-modulated radiation therapy. For rectal cancer, clinical trials have established the role for neoadjuvant therapy for T3-4 and/or node-positive tumor presentations. Chemotherapy and targeted agents are under study in both anal and rectal cancers to improve on the standard combinations of chemotherapy and radiation.

Full Text

Duke Authors

Cited Authors

  • Czito, BG; Meyer, J

Published Date

  • July 2013

Published In

Volume / Issue

  • 22 / 3

Start / End Page

  • 525 - 543

PubMed ID

  • 23622078

Electronic International Standard Serial Number (EISSN)

  • 1558-5042

Digital Object Identifier (DOI)

  • 10.1016/j.soc.2013.02.010


  • eng

Conference Location

  • United States