Acid phosphatase positivity in childhood acute lymphocytic leukemia.

Journal Article (Journal Article)

The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.

Full Text

Duke Authors

Cited Authors

  • Head, DR; Borowitz, M; Cerezo, L; Craven, CM; Brock, BL; Boyett, JM; Pullen, DJ; Crist, WM; Falletta, J; Humphrey, GB

Published Date

  • November 1986

Published In

Volume / Issue

  • 86 / 5

Start / End Page

  • 650 - 653

PubMed ID

  • 3465229

International Standard Serial Number (ISSN)

  • 0002-9173

Digital Object Identifier (DOI)

  • 10.1093/ajcp/86.5.650


  • eng

Conference Location

  • England