Identifying serotonergic mechanisms underlying the corticolimbic response to threat in humans.

Journal Article (Review;Journal Article)

A corticolimbic circuit including the amygdala and medial prefrontal cortex (mPFC) plays an important role in regulating sensitivity to threat, which is heightened in mood and anxiety disorders. Serotonin is a potent neuromodulator of this circuit; however, specific serotonergic mechanisms mediating these effects are not fully understood. Recent studies have evaluated molecular mechanisms mediating the effects of serotonin signalling on corticolimbic circuit function using a multi-modal neuroimaging strategy incorporating positron emission tomography and blood oxygen level-dependent functional magnetic resonance imaging. This multi-modal neuroimaging strategy can be integrated with additional techniques including imaging genetics and pharmacological challenge paradigms to more clearly understand how serotonin signalling modulates neural pathways underlying sensitivity to threat. Integrating these methodological approaches offers novel opportunities to identify mechanisms through which serotonin signalling contributes to differences in brain function and behaviour, which in turn can illuminate factors that confer risk for illness and inform the development of more effective treatment strategies.

Full Text

Duke Authors

Cited Authors

  • Fisher, PM; Hariri, AR

Published Date

  • January 2013

Published In

Volume / Issue

  • 368 / 1615

Start / End Page

  • 20120192 -

PubMed ID

  • 23440464

Pubmed Central ID

  • PMC3638383

Electronic International Standard Serial Number (EISSN)

  • 1471-2970

International Standard Serial Number (ISSN)

  • 0962-8436

Digital Object Identifier (DOI)

  • 10.1098/rstb.2012.0192


  • eng