The tangled circuitry of metabolism and apoptosis.

Journal Article (Review;Journal Article)

For single-cell organisms, nutrient uptake and metabolism are central to the fundamental decision of whether to grow or divide. In metazoans, cell fate decisions are more complex: organismal homeostasis must be strictly maintained by balancing cell proliferation and death. Despite this increased complexity, cell fate within multicellular organisms is also influenced by metabolism; recent studies, triggered in part by an interest in tumor metabolism, are beginning to illuminate the mechanisms through which proliferation, death, and metabolism are intertwined. In particular, work on Bcl-2 family proteins suggests that the signaling pathways governing metabolism and apoptosis are inextricably linked. Here we review the crosstalk between these pathways, emphasizing recent work that illustrates the emerging dual nature of several core apoptotic proteins in regulating both metabolism and cell death.

Full Text

Duke Authors

Cited Authors

  • Andersen, JL; Kornbluth, S

Published Date

  • February 2013

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • 399 - 410

PubMed ID

  • 23395270

Pubmed Central ID

  • PMC3801185

Electronic International Standard Serial Number (EISSN)

  • 1097-4164

International Standard Serial Number (ISSN)

  • 1097-2765

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2012.12.026


  • eng