Efficient trial designs to reduce placebo requirements.

Journal Article

This brief discussion summarizes possible trial design changes that could be utilized to reduce the number of subjects exposed to ineffective treatment--in this case placebo; however, these designs are fairly complex and have not been implemented sufficiently to judge their utility. Clearly, such studies are essential before embarking on these paradigms as a primary method for assessing antidepressant efficacy.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR

Published Date

  • April 15, 2000

Published In

Volume / Issue

  • 47 / 8

Start / End Page

  • 724 - 726

PubMed ID

  • 10773179

Pubmed Central ID

  • 10773179

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(99)00320-0


  • eng

Conference Location

  • United States