Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens.

Journal Article (Clinical Trial;Journal Article)

UNLABELLED: We initiated a pilot study to investigate the effects of 8 wks of aerobic exercise training (ET) on insulin sensitivity and inflammatory markers in obese and insulin-resistant minority adolescents. Eleven morbidly obese (BMI 41.4 ± 1.8 kg/m2) minority adolescents were entered into a supervised ET intervention (~180 min/wk at 40-55%VO2PeakR [(VO2Peak-VO2Rest)/VO2Rest]). The effects of training on insulin sensitivity (SI), inflammation and other metabolic syndrome features were examined. RESULTS: Insulin action improved in response to training, as indicated by a ~37% increase in SI (p = .018). Plasma levels of several proinflammatory cytokines were reduced in response to ET, as indicated by significant decrements in sTNF-R, CCL2, MPO, IL-6, resistin, and leptin, with no significant changes in hsCRP. ET induced reductions in BMI and percent total body fat. CONCLUSIONS: The present study supports the efficacy of ET interventions on metabolic syndrome features in morbidly obese minority youth.

Full Text

Duke Authors

Cited Authors

  • Many, G; Hurtado, M-E; Tanner, C; Houmard, J; Gordish-Dressman, H; Park, J-J; Uwaifo, G; Kraus, W; Hagberg, J; Hoffman, E

Published Date

  • February 2013

Published In

Volume / Issue

  • 25 / 1

Start / End Page

  • 12 - 26

PubMed ID

  • 23406700

Electronic International Standard Serial Number (EISSN)

  • 1543-2920

Digital Object Identifier (DOI)

  • 10.1123/pes.25.1.12


  • eng

Conference Location

  • United States