Growth hormone response to growth hormone-releasing factor in depression.


Journal Article

A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine has led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypothesis is based on the assumption that the pituitary somatotroph response to growth hormone-releasing factor (GHRF) is not altered in depression. In the present preliminary study, the somatotroph response to GHRF in depressed patients and normal controls has been evaluated in four depressed patients and four age- and sex-matched controls. The GH response to GRF is highly variable both in normal individuals and in the depressed patients studied. Larger numbers of patients and controls must be studied before any definitive conclusions can be drawn about GH responses to GRF in depressed patients.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Manepalli, AN; Ritchie, JC; Rayasam, K; Melville, ML; Thorner, MO; Rivier, JE; Vale, WW; Nemeroff, CB

Published Date

  • 1988

Published In

Volume / Issue

  • 9 Suppl 1 /

Start / End Page

  • 113 - 116

PubMed ID

  • 2856637

Pubmed Central ID

  • 2856637

International Standard Serial Number (ISSN)

  • 0196-9781

Digital Object Identifier (DOI)

  • 10.1016/0196-9781(88)90234-3


  • eng

Conference Location

  • United States