Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats

Journal Article

An ethanol-preferring line of rats, developed by selective breeding, consumed as much as 9.4 ± 1.7 grams of ethanol per kilogram of body weight per day through intragastric self-infusions, yielding blood ethanol concentrations of 92 to 415 milligrams per 100 milliliters. By contrast, the ethanol-nonpreferring line self-administered only 0.7 ± 0.2 gram per kilogram per day. These findings indicate that the reinforcing effect of ethanol is postabsorptive and is not mediated by the drug's smell or taste. Hence the ethanol-preferring line of rats may be a suitable animal model of alcoholism.

Full Text

Cited Authors

  • Waller, MB; McBride, WJ; Gatto, GJ; Lumeng, L; Li, TK

Published Date

  • 1984

Published In

Volume / Issue

  • 225 / 4657

Start / End Page

  • 78 - 80

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6539502