Marrow transplantation for acute nonlymphocytic leukemia following therapy for Hodgkin's disease.

Published

Journal Article

Seven patients with acute nonlymphocytic leukemia (ANL) following therapy for Hodgkin's disease (HD) were treated with cyclophosphamide (Cy) alone or combined with 10.00 to 15.75 Gy total body irradiation (TBI) and marrow transplantation. Five patients were transplanted without an attempt at prior remission induction, one patient following failure of remission induction and one patient in first remission following successful induction. Four patients died of multiorgan failure, 15 to 70 days after transplant. Three patients died of progressive or recurrent leukemia 56, 120, and 280 days after transplant. These results illustrate the difficulty of treating patients for secondary leukemia with marrow transplantation and suggest that transplantation in the preleukemic phase should be studied.

Full Text

Duke Authors

Cited Authors

  • Sargur, M; Buckner, CD; Appelbaum, FR; Stewart, P; Deeg, HJ; Weiden, PL; Sullivan, KM; Fefer, A; Thomas, ED

Published Date

  • May 1987

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 731 - 734

PubMed ID

  • 3553436

Pubmed Central ID

  • 3553436

International Standard Serial Number (ISSN)

  • 0732-183X

Digital Object Identifier (DOI)

  • 10.1200/JCO.1987.5.5.731

Language

  • eng

Conference Location

  • United States