Severe aplastic anemia associated with chronic mucocutaneous candidiasis. Immunologic and hematologic reconstitution after allogeneic bone marrow transplantation.

Published

Journal Article

Chronic mucocutaneous candidiasis (CMC) is typically associated with the inability of T lymphocytes to proliferate and produce lymphokines in response to Candida antigen. A 7-year-old girl with CMC developed severe aplastic anemia and, after conditioning with cyclophosphamide, 200 mg/kg, underwent bone marrow transplantation from her HLA-identical sister. Engraftment was prompt and complete. The patient is surviving more than 3 years after transplantation with normal donor-derived hemopoiesis and immune function. Manifestations of CMC have resolved completely and she has not received antifungal therapy for more than 2 years.

Full Text

Duke Authors

Cited Authors

  • Deeg, HJ; Lum, LG; Sanders, J; Levy, GJ; Sullivan, KM; Beatty, P; Thomas, ED; Storb, R

Published Date

  • May 1, 1986

Published In

Volume / Issue

  • 41 / 5

Start / End Page

  • 583 - 586

PubMed ID

  • 3518164

Pubmed Central ID

  • 3518164

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-198605000-00006

Language

  • eng

Conference Location

  • United States