Severe aplastic anemia associated with chronic mucocutaneous candidiasis. Immunologic and hematologic reconstitution after allogeneic bone marrow transplantation

Journal Article

Chronic mucocutaneous candidiasis (CMC) is typically associated with the inability of T lymphocytes to proliferate and produce lymphokines in response to Candida antigen. A 7-year-old girl with CMC developed severe aplastic anemia and, after conditioning with cyclophosphamide, 200 mg/kg, underwent bone marrow transplantation from her HLA-identical sister. Engraftment was prompt and complete. The patient is surviving more than 3 years after transplantation with normal donor-derived hemopoiesis and immune function. Manifestations of CMC have resolved completely and she has not received antifungal therapy for more than 2 years.

Duke Authors

Cited Authors

  • Deeg, HJ; Lum, LG; Sanders, J; Levy, GJ; Sullivan, KM; Beatty, P; Thomas, ED; Storb, R

Published Date

  • 1986

Published In

Volume / Issue

  • 41 / 5

Start / End Page

  • 583 - 586

PubMed ID

  • 3518164

International Standard Serial Number (ISSN)

  • 0041-1337